Subunits with Two Transmembrane Domains

These pore forming subunits are components of inward rectifying K+ (Kir) channels. Kir principal subunits have a predicted membrane topology of two TMDs (M1-M2) and a pore domain located between the two TMDs. Their primary structure is thus analogous to the S5-P-S6 region of the 6TMD K+ channel subunits. .

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Last updated: March 9, 2003
Based on data as published in: Coetzee, W.A., Y. Amarillo, J. Chiu, A. Chow, T. McCormack, H. Moreno, M. Nadal, A. Ozaita, D. Pountney, E. Vega-Saenz de Miera, and B. Rudy. Molecular Diversity of K+ Channels. In: Molecular and Functional Diversity of Ion Channels and Receptors, edited by B. Rudy and P. Seeburg. New York: New York Academy of Sciences, 1999. [Download PDF file]