Subunits with Six Transmembrane Domains
The principal subunits contain six transmembrane domains (TMDs; S1-S6), with a conserved P (pore or H5) domain, which forms the lining of the selectivity filter of the channel's pore. Functionally, they form voltage- and/or Ca2+-activated K+ channels when expressed in heterologous expression systems. This group contains:
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Kv family (with eight subfamilies; Kv1-Kv6 and Kv8-Kv9)
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Members of the KCNQ and eag (with three subfamilies eag, erg and elk)
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Ca2+-activated K+ channel families of principal subunits (SK and Slo).
Please select a subunit family by clicking on the image for detailed information
Last updated: March 9, 2003
Based on data as published in: Coetzee, W.A., Y. Amarillo, J. Chiu, A. Chow, T. McCormack, H. Moreno, M. Nadal, A. Ozaita, D. Pountney, E. Vega-Saenz de Miera, and B. Rudy. Molecular Diversity of K+ Channels. In: Molecular and Functional Diversity of Ion Channels and Receptors, edited by B. Rudy and P. Seeburg. New York: New York Academy of Sciences, 1999. [Download PDF file]