Genes encoding auxiliary subunits of Kv and eag channels

Gene

Gene locus designation

Other names

Alpha Partner

Chromosome localization

Genomic organization

Accession Number

Associated Diseases

 

Kvb1

KCNAB1

HKvb3, hKvb1.3

 

3q26.1

14 exons over 380 kb

L47665

 

 

Kvb2

KCNAB2

hKvb2.1

 

1p36.3

15 exons spanning 70 kb

U33429

 

 

Kvb3

KCNAB3

KCNA3.1B

 

17q13.1

14 exons spanning 11 kb

AF016411

 

 

KChAP

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

minK

KCNE1

ISK, IsK, JLNS, LQT5

KvLQT1

21q22.1-q22.2

3 exons

L28168

Jervell and Lange-Nielsen syndrome

 

 

 

 

 

 

 

 

 

MiRP1

KCNE2

LQT5, LQT6

HERG

Kv4.2

HCN

21q22.1

 

AF071002

Long QT syndrome-6

 

MiRP2

KCNE3

HOKPP

Kv3.4

11q13-q14

 

AF076531

Hypokalemic Periodic Paralysis

 

 

 

 

 

 

 

 

 

 

 

KCNE1L

 

??

Xq22.3

 

AJ012743

Alport syndrome

 

 

 

 

 

 

 

 

 

 

KCR1

 

 

EAG

 

 

U78090[1]

 

 

 

 

 

 

 

 

 

 

 

KChIP1

KCNIP1

 

Kv4

5

7 exons

AF199597

 

 

KChIP2

KCNIP2

 

Kv4

10q24

 

AF199598

 

 

KChIP3

CSEN

Calsenilin, DREAM, KCNIP3

Kv4

2

 

AF199599

 

 

KChIP4

KCNIP4

 

No data

4

 

AF367023

 

 

Frequenin

FREQ

NCS1

Kv4[2]

9q34

 

AF186409

 

 

 

 

 

 

 

 

 

 

 



[1] No human homologue has been described to date

[2] Circulation, 102 (18): 432 Suppl. S, 2000

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Last updated: March 9, 2003
Based on data as published in: Coetzee, W.A., Y. Amarillo, J. Chiu, A. Chow, T. McCormack, H. Moreno, M. Nadal, A. Ozaita, D. Pountney, E. Vega-Saenz de Miera, and B. Rudy. Molecular Diversity of K+ Channels. In: Molecular and Functional Diversity of Ion Channels and Receptors, edited by B. Rudy and P. Seeburg. New York: New York Academy of Sciences, 1999. [Download PDF file]